Murotsuki J, Okamura K, Watanabe T, Endo H, Iwamoto M, Tsujiei M, Furuhashi N, Yajima A
Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai.
Nihon Sanka Fujinka Gakkai Zasshi. 1991 Mar;43(3):304-8.
Severe preeclampsia in the second trimester presents a major challenge in management because it is associated with high perinatal mortality. One possible way to improve the perinatal outcome in these pregnancies is to predict the later development of preeclampsia and to start management of it early. To investigate the relationship between the timing of the rise in maternal mean arterial pressure (MAP) and the course of biparietal diameter (BPD) growth in the fetus, we reviewed seven women with preeclampsia diagnosed between 18 and 27 weeks' gestation. MAP increased slowly within the normal range three or four weeks before the onset of the disease. Slowing of the fetal BPD growth curve preceded the onset of preeclampsia by two to four weeks. Serial measurement of BPD from early pregnancy may prevent the onset of severe preeclampsia before 28 weeks' gestation.
孕中期重度子痫前期在管理方面面临重大挑战，因为它与高围产期死亡率相关。改善这些妊娠围产期结局的一种可能方法是预测子痫前期的后期发展并尽早开始管理。为了研究孕妇平均动脉压（MAP）升高时间与胎儿双顶径（BPD）生长过程之间的关系，我们回顾了7例在妊娠18至27周期间被诊断为子痫前期的妇女。在疾病发作前三到四周，MAP在正常范围内缓慢升高。胎儿BPD生长曲线的放缓比子痫前期发作提前两到四周。从早孕开始连续测量BPD可能预防妊娠28周前重度子痫前期的发作。
