Department of Forensic Medicine, Medical University of Gdansk, Gdansk, Poland.
Forensic Sci Int Genet. 2011 Jan;5(1):e17-20. doi: 10.1016/j.fsigen.2009.10.011. Epub 2009 Nov 25.
Nine loci defining minimal haplotypes and four other Y-chromosomal short tandem repeats (Y-STRs) DYS437, DYS438, DYS439 and GATA H4.1 were analysed in 414 unrelated males residing in four regions of Belarus. Haplotypes of 328 males were further extended by 7 additional Y-STRs: DYS388, DYS426, DYS448, DYS456, DYS458, DYS460 and DYS635. The 13-locus haplotype diversity was 0.9978 and discrimination capacity was 78.7%, indicating presence of identical haplotypes among unrelated males. Seven additional Y-STRs enabled almost complete discrimination of undifferentiated 13-locus haplotypes, increasing haplotype diversity to 0.9998 and discrimination capacity to 97.9%. Analysis of molecular variance of minimal haplotypes excluded the use of a Y-STR database for Belarusians residing in northeastern Poland as representative for the Belarusian population in forensic practice, and revealed regional stratification within the country. However, four additional markers (DYS437, DYS438, DYS439 and GATA H4.1) were shown to eliminate the observed geographical substructure among Belarusian males. The results imply that in case of minimal and PowerPlex Y haplotypes, a separate frequency database should be used for northern Belarus to estimate Y-STR profile frequencies in forensic casework. In case of Yfiler haplotypes, regional stratification within Belarus may be neglected.
在 414 名居住在白俄罗斯四个地区的无关男性中，分析了 9 个定义最小单倍型的基因座和另外 4 个 Y 染色体短串联重复（Y-STR）DYS437、DYS438、DYS439 和 GATA H4.1。进一步扩展了 328 名男性的单倍型，增加了 7 个额外的 Y-STR：DYS388、DYS426、DYS448、DYS456、DYS458、DYS460 和 DYS635。13 个基因座的单倍型多样性为 0.9978，鉴别能力为 78.7%，表明无关男性之间存在相同的单倍型。另外 7 个 Y-STR 几乎可以完全区分未分化的 13 个基因座单倍型，将单倍型多样性提高到 0.9998，鉴别能力提高到 97.9%。最小单倍型的分子方差分析排除了使用居住在波兰东北部的白俄罗斯人的 Y-STR 数据库作为法医实践中白俄罗斯人口的代表，并且揭示了该国内部的区域分层。然而，另外四个标记物（DYS437、DYS438、DYS439 和 GATA H4.1）被证明可以消除白俄罗斯男性之间观察到的地理亚结构。结果表明，在最小和 PowerPlex Y 单倍型的情况下，应该为白俄罗斯北部使用单独的频率数据库来估计法医工作中的 Y-STR 图谱频率。在 Yfiler 单倍型的情况下，可以忽略白俄罗斯内部的区域分层。
Zotero 插件