PIVET Medical Centre, 166-168 Cambridge Street, Leederville, Perth 6007, Australia.
Reprod Biomed Online. 2010 Jul;21(1):37-49. doi: 10.1016/j.rbmo.2010.03.013. Epub 2010 Apr 2.
In a sequential crossover study of IVF conducted from 2002 to 2006, growth hormone (GH) supplementation was assessed in poor-prognosis patients, categorized on the basis of past failure to conceive (mean 3.05 cycles) due to low response to high-dose stimulation (<3 metaphase II oocytes) or poor-quality embryos. Pregnancy rates in both fresh and frozen transfer cycles and the total productivity rates (fresh and frozen pregnancies per egg collection) were compared. In all, 159 patients had 488 treatment cycles: 221 with GH and 241 without GH. These cycles were also compared with 1572 uncategorized cycles from the same period. GH co-treatment significantly improved the clinical pregnancy rate per fresh transfer (P<0.001) as well as per frozen-thawed embryo derived from GH cycles (P<0.05) creating a highly significant productivity rate (P<0.001). The effect was significant across all age groups, especially in younger patients, and was independent of stimulation modality or number of transfers. GH cycles resulted in significantly more babies delivered per transfer than non-GH cycles (20% versus 7%; P<0.001) although less than the uncategorized cycles (53%). The data uniquely show that the effect of GH is directed at oocyte and subsequent embryo quality.
在一项 2002 年至 2006 年进行的 IVF 序贯交叉研究中，评估了生长激素（GH）对预后不良患者的补充作用，这些患者是根据既往因高剂量刺激反应不良（<3 个中期 II 卵母细胞）或胚胎质量差而导致受孕失败（平均 3.05 个周期）进行分类的。比较了新鲜和冷冻移植周期的妊娠率以及总产率（每个取卵周期的新鲜和冷冻妊娠）。共有 159 名患者接受了 488 个治疗周期：221 个接受了 GH 治疗，241 个未接受 GH 治疗。这些周期也与同期的 1572 个未分类周期进行了比较。GH 联合治疗显著提高了新鲜移植周期的临床妊娠率（P<0.001）以及来自 GH 周期的冷冻解冻胚胎的妊娠率（P<0.05），从而产生了非常显著的产率（P<0.001）。这种效果在所有年龄组中都是显著的，尤其是在年轻患者中，并且独立于刺激方式或移植次数。GH 周期每移植产生的婴儿数量明显多于非 GH 周期（20%比 7%；P<0.001），尽管少于未分类周期（53%）。这些数据独特地表明，GH 的作用是针对卵母细胞和随后的胚胎质量的。
