Department of Biochemistry, La Trobe University, Bundoora, Victoria, Australia.
Lab Anim. 2010 Jul;44(3):271-3. doi: 10.1258/la.2010.009148. Epub 2010 May 10.
Parasitic infections are a concern in animal facilities, in view of their influence on physiological processes and the immune status of animals. Pinworms are effectively controlled with the anthelminthic fenbendazole (FBZ, [5-(phenylthio)-1H-benzamidazol-2-yl]carbamic acid methyl ester; C(15)H(13)N(3)O(2)S); however, questions remain as to whether prolonged FBZ exposure alters the disease course in specific experimental models, such as those pertaining to the immune system. We report that a three-month regimen of FBZ-medicated feed severely affected the onset and disease severity of murine experimental autoimmune encephalomyelitis (EAE), a disease that mimics multiple sclerosis. Differences were recorded between mouse strains used. Our data suggest that where the use of FBZ is mandatory, its full effect should be verified on the particular EAE variant adopted by the laboratory.
寄生虫感染是动物设施中的一个关注点，因为它们会影响动物的生理过程和免疫状态。苯硫苯咪唑（fenbendazole，FBZ，[5-(苯基硫代)-1H-苯并咪唑-2-基]氨基甲酸甲酯；C(15)H(13)N(3)O(2)S）可有效控制寄生蠕虫病；然而，人们仍不清楚长时间接触 FBZ 是否会改变特定实验模型（如免疫系统相关模型）中的疾病进程。我们的报告显示，三个月的 FBZ 饲料疗程严重影响了实验性自身免疫性脑脊髓炎（EAE）的发病和严重程度，EAE 是一种模拟多发性硬化症的疾病。不同的小鼠品系存在差异。我们的数据表明，在必须使用 FBZ 的情况下，应在实验室采用的特定 EAE 变异体上验证其全部效果。
