Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
Shock. 2010 Dec;34(6):548-57. doi: 10.1097/SHK.0b013e3181e686f5.
Toll-like receptors (TLRs) play a key role in innate immune defenses. After activation by foreign pathogens or host-derived molecules, TLRs signal via overlapping or distinct signaling cascades and eventually induce numerous genes involved in a variety of cellular responses. A growing body of evidence suggests that TLR signaling also plays an important role in cardiac ischemia/reperfusion injury. We review our current understanding of the TLR signaling pathways and their roles in the pathophysiology of cardiac ischemia/reperfusion injury, as well as discuss several mechanisms for TLR activation and regulation.
Toll 样受体（TLRs）在先天免疫防御中发挥关键作用。在被外来病原体或宿主来源的分子激活后，TLRs 通过重叠或不同的信号级联传递信号，最终诱导多种参与各种细胞反应的基因。越来越多的证据表明，TLR 信号在心肌缺血/再灌注损伤中也起着重要作用。我们综述了目前对 TLR 信号通路及其在心肌缺血/再灌注损伤病理生理学中的作用的理解，并讨论了 TLR 激活和调节的几种机制。
