Laboratório de Virologia Humana, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia-Goiás, Brazil.
Med Microbiol Immunol. 2011 Feb;200(1):13-22. doi: 10.1007/s00430-010-0160-3. Epub 2010 May 11.
During HBV infection, four structural antigen/antibody systems are observed: hepatitis B surface antigen (HBsAg) and its antibody (anti-HBs); the pre-S antigens associated with HBsAg particles and their antibodies; the particulate nucleocapsid antigen (HBcAg) and anti-HBc; and an antigen structurally related to HBcAg, namely HBeAg and its antibody (anti-HBe). Through the examination of this antigen-antibodies system, hepatitis B infection is diagnosed and the course of the disorder may be observed. Isolated HBsAg seropositivity is a peculiar serological pattern in HBV infection observed some times in routine laboratory. In most cases is not clear how this profile should be interpreted neither its significance. This pattern, however, may be associated with some clinical and laboratorial situations of great relevance, some of which will be addressed in this article.
在乙型肝炎病毒感染期间，观察到四个结构抗原/抗体系统：乙型肝炎表面抗原 (HBsAg) 及其抗体 (抗-HBs)；与 HBsAg 颗粒相关的前 S 抗原及其抗体；颗粒核衣壳抗原 (HBcAg) 和抗-HBc；以及一种与 HBcAg 结构相关的抗原，即 HBeAg 和其抗体 (抗-HBe)。通过检查这个抗原-抗体系统，可以诊断乙型肝炎感染，并观察疾病的进程。在常规实验室中，有时会观察到乙型肝炎病毒感染中出现单独的 HBsAg 血清阳性，这是一种特殊的血清学模式。在大多数情况下，不清楚如何解释这种模式及其意义。然而，这种模式可能与一些具有重要临床和实验室意义的情况相关，本文将讨论其中一些情况。
