Laboratory of Human Virology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, Goiás, Brazil.
Secretaria de Estado da Saúde -SES/Superintendência de Vigilância em Saúde-SUVISA/GO, Gerência de Vigilância Epidemiológica-GVE/Coordenação de Análises e Pesquisas-CAP, Goiânia, Goiás, Brazil.
Mol Biol Rep. 2021 Jan;48(1):843-854. doi: 10.1007/s11033-020-06056-4. Epub 2020 Dec 9.
Wild-type HBV infection is followed by the blood expression of its widely known serological markers of infection, and designated as, hepatitis B virus surface antigen (HBsAg) and its antibody (anti-HBs), anti-HBc antibodies (IgM/IgG), and hepatitis B virus 'e' antigen (HBeAg) and its antibody (anti-HBe). These markers are detected as the infection develops and its kinetic behavior serves as a basis for monitoring the disorder and for diagnosing the clinical form or infection phase. Among these, the HBeAg-anti-HBe system markers demonstrate a dynamic profile whose interpretation, both in the acute or chronic HBV infection context, can offer greater difficulty to the health professionals, due to its particularities. This review offers a revisit to the markers dynamics of this system in the acute and chronic HBV infection and to the clinical and laboratory significance of its expression in these two clinical contexts.
野生型 HBV 感染后，其广泛存在的血清学感染标志物会在血液中表达，并被指定为乙型肝炎病毒表面抗原 (HBsAg) 及其抗体 (抗-HBs)、抗-HBc 抗体 (IgM/IgG)，以及乙型肝炎病毒 'e' 抗原 (HBeAg) 和其抗体 (抗-HBe)。这些标志物在感染发展过程中被检测到，其动力学行为可作为监测疾病和诊断临床形式或感染阶段的基础。在这些标志物中，HBeAg-抗-HBe 系统标志物呈现出动态特征，由于其特殊性，无论是在急性还是慢性 HBV 感染的情况下，其解读对于卫生专业人员来说都可能更加困难。本综述回顾了该系统在急性和慢性 HBV 感染中的标志物动力学，以及其在这两种临床情况下表达的临床和实验室意义。
