Liu Jun-ling, Wang Jun-ying, Chen Shu-ping, Gao Yong-hui, Qiao Li-na, Han Yan-jing
Institute of Acu-moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Zhen Ci Yan Jiu. 2010 Feb;35(1):71-7.
In the present paper, the authors review development of studies on the mechanism underlying the correlation between acupoints/ meridians and internal organs in recent 10 years from (1) doctrine of "dynamic acupoint"; (2) effect of one acupoint-stimulation on multi-viscera, (3) effect of multi-acupoints/multi-meridians stimulation on one single internal organ, (4) specific reactions of visceral disorders on the body surface, (5) the therapeutic effect of acupoint-injection being better than muscular injection, (6) effect of acupuncture on the expression of some known intracellular genes/proteins of the related viscera, (7) effect of acupuncture on the expression or phosphorylation of whole genes/whole proteins of the related viscera, (8) peripheral pathways connecting acupoints and the associated internal organ, (9) central pathways connecting acupoints and the related viscera, and (10) overview of the similar researches in foreign countries. In addition, the authors also make a preliminary analysis on the research significance, current problems and the thoughts in the coming studies. Utilizing advanced knowledge and techniques of systems biology to study "the correlation between acupoints/meridians and internal organs" will greatly promote the development of acupuncturology.
在本文中，作者从以下几个方面综述了近10年穴位/经络与内脏相关性机制的研究进展：（1）“动态穴位”学说；（2）单穴刺激对多脏器的影响；（3）多穴/多经刺激对单一内脏的影响；（4）内脏病变在体表的特异性反应；（5）穴位注射疗效优于肌肉注射；（6）针刺对相关内脏某些已知细胞内基因/蛋白质表达的影响；（7）针刺对相关内脏全基因/全蛋白质表达或磷酸化的影响；（8）连接穴位与相关内脏的外周通路；（9）连接穴位与相关内脏的中枢通路；（10）国外类似研究概况。此外，作者还对研究意义、存在问题及未来研究思路进行了初步分析。运用系统生物学的先进知识和技术研究“穴位/经络与内脏的相关性”将极大地推动针灸学的发展。
