Department of Biomedical Kinesiology, Research Center for Exercise and Health, Faculty of Kinesiology and Rehabilitation Sciences, Katholieke Universiteit Leuven, Leuven, Belgium.
Scand J Med Sci Sports. 2011 Aug;21(4):580-8. doi: 10.1111/j.1600-0838.2009.01082.x. Epub 2010 Mar 10.
Repeated, intense use of muscles leads to a decline in performance known as muscle fatigue. Resistance to muscle fatigue depends on age, sex, muscle fiber type, activation by the nervous system and training. Heritability of muscle strength phenotypes ranges between 31% and 78%, although little is known about heritability of muscle fatigue. A first aim of this study was to estimate the heritability for fatigue resistance after a short bout of intense exercise of the knee musculature. The main purpose was to identify chromosomal regions linked to muscle fatigue applying genome-wide linkage analyses. A selection of 283 informative male siblings (17-36 years old), belonging to 105 families, was used to conduct a genome-wide SNP-based multipoint linkage analysis. Heritabilities for resistance to muscle fatigue ranged from 21% to 54%. The strongest linkage signal was found at 19q13.11 (LOD=2.158; P<0.0001) and at 1q32.1 (LOD=2.142; P<0.0001) for resistance to fatigue of the knee flexors; however, no marker reached genome-wide significance. Several other regions with LOD>1.5 were found (1p31.3, 3q29, 8p22, 11q25 and 19q12). When replicated in an independent sample, these results warrant further fine mapping studies aiming to detect genes that underlie variation in muscle fatigue.
肌肉的重复、高强度使用会导致肌肉疲劳，表现为运动能力下降。肌肉疲劳的抵抗力取决于年龄、性别、肌肉纤维类型、神经系统的激活和训练。肌肉力量表型的遗传率在 31%到 78%之间，尽管肌肉疲劳的遗传率知之甚少。本研究的第一个目的是估计膝关节肌肉短暂剧烈运动后疲劳抵抗的遗传率。主要目的是应用全基因组连锁分析来确定与肌肉疲劳相关的染色体区域。选择了 105 个家庭的 283 名有信息的男性同胞（17-36 岁）进行全基因组 SNP 多点连锁分析。肌肉疲劳抵抗力的遗传率范围为 21%至 54%。在股四头肌疲劳抵抗方面，最强的连锁信号位于 19q13.11（LOD=2.158；P<0.0001）和 1q32.1（LOD=2.142；P<0.0001），但没有一个标记达到全基因组显著水平。还发现了其他几个 LOD>1.5 的区域（1p31.3、3q29、8p22、11q25 和 19q12）。在独立样本中复制这些结果后，需要进一步进行精细定位研究，以检测导致肌肉疲劳变异的基因。
