Department of Anatomical Pathology, Concord Hospital, and Discipline of Pathology, The University of Sydney, Sydney, New South Wales, Australia.
Histopathology. 2010 Feb;56(3):319-30. doi: 10.1111/j.1365-2559.2010.03479.x.
The tumour suppressor maspin has been investigated for its association with conventional histopathological features in colorectal cancer and for its potential as an independent predictor of survival and response to adjuvant chemotherapy. The aim of this study was to examine associations between maspin expression, other histopathology and survival in a large consecutive series of patients after potentially curative resection of node-positive colonic adenocarcinoma.
Nuclear and cytoplasmic maspin expression in both superficial and deep parts of the tumour were assessed retrospectively by tissue microarray and immunohistochemistry in specimens from 450 patients whose other histopathology had been recorded in a prospective hospital registry of large bowel cancer resections from 1971 to 2001 with a minimum follow-up of 5 years. Among 13 clinicopathological features examined, the only associations that persisted across all four maspin assessments were stronger expression in right- than in left-sided tumours (P=0.001-0.011) and stronger expression in high-grade tumours (P<0.001-0.007). There was no significant association between intensity of maspin expression and overall survival.
In this large and thoroughly documented series of patients with clinicopathological stage C colonic tumour, maspin expression was correlated with few other conventional histopathology variables and was not a significant prognostic factor.
肿瘤抑制因子 maspin 已被研究用于其与结直肠癌常规组织病理学特征的关联，以及作为生存和对辅助化疗反应的独立预测因子的潜力。本研究的目的是在接受潜在根治性切除的淋巴结阳性结肠腺癌患者的大型连续系列中，检查 maspin 表达、其他组织病理学和生存之间的关联。
通过组织微阵列和免疫组织化学，对 450 名患者的标本进行了回顾性核和细胞质 maspin 表达评估，这些患者的其他组织病理学特征记录在 1971 年至 2001 年期间前瞻性医院大型肠结直肠癌切除登记处，随访时间至少为 5 年。在检查的 13 个临床病理特征中，唯一在所有四个 maspin 评估中都持续存在的关联是右侧肿瘤比左侧肿瘤的表达更强（P=0.001-0.011）和高级别肿瘤的表达更强（P<0.001-0.007）。maspin 表达强度与总生存无显著相关性。
在本系列具有临床病理分期 C 结肠肿瘤的大型且记录详尽的患者中，mpsin 表达与其他少数常规组织病理学变量相关，并且不是重要的预后因素。
