γ-内酯型唾液酸（2,3-脱氢唾液酸的一种异构体）的合成
Synthesis of gamma-lactone-type sialic acid, an isomer of 2,3-dehydrosialic acid.
作者信息
Sawada Yoshiharu, Nakatsuka Shin-ichi
机构信息
The United Graduate School of Agricultural Science, Gifu University, Gifu, Japan.
出版信息
Biosci Biotechnol Biochem. 2010;74(5):1106-7. doi: 10.1271/bbb.90912. Epub 2010 May 7.
PMID:20460706
Abstract
An efficient synthesis of gamma-lactone-type sialic acid, which is an isomer of 2,3-dehydrosialic acid, was achieved from the corresponding sialic ester. The sialic ester was reconstructed from the gamma-lactone in a 95% yield. The gamma-lactone structure was determined by methylating to its corresponding methyl ether.
摘要
从相应的唾液酸酯实现了γ-内酯型唾液酸（2,3-脱氢唾液酸的异构体）的高效合成。唾液酸酯由γ-内酯以95%的产率重构得到。γ-内酯结构通过将其甲基化转化为相应的甲基醚来确定。
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