N-乙酰神经氨酸1,7-内酯的首次合成。
The first synthesis of N-acetylneuraminic acid 1,7-lactone.
作者信息
Colombo Raffaele, Anastasia Mario, Rota Paola, Allevi Pietro
机构信息
Department of Chemistry, Biochemistry and Biotechnology for the Medicine, Via Saldini 50, Milano, Italy.
出版信息
Chem Commun (Camb). 2008 Nov 21(43):5517-9. doi: 10.1039/b810447f. Epub 2008 Sep 23.
DOI:10.1039/b810447f
PMID:18997937
Abstract
N-Acetylneuraminic acid is transformed into its until now unavailable and rather unwieldy 1,7-lactone, via the manageable 2-benzyloxycarbonyl N-acetylneuraminic acid 1,7-lactone which generates the free lactone in quantitative yield by hydrogenolysis.
摘要
N-乙酰神经氨酸通过易于处理的2-苄氧羰基N-乙酰神经氨酸1,7-内酯转化为其迄今为止无法获得且相当难以处理的1,7-内酯，该2-苄氧羰基N-乙酰神经氨酸1,7-内酯通过氢解以定量产率生成游离内酯。
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