Departments of Radiology and Neurological Surgery, Columbia University, New York, NY, USA.
Curr Atheroscler Rep. 2010 Jul;12(4):244-50. doi: 10.1007/s11883-010-0115-6.
Ischemic stroke remains one of the leading cause of adult death and disability in the United States. Reperfusion of the occluded vessel is the standard of care in the setting of acute ischemic stroke according to established guidelines. Since the introduction of intravenous (IV) recombinant tissue plasminogen activator (rt-PA) in the late 1990s, significant advances have been made in methods to deliver thrombolytic agents and in devices for mechanical recanalization of occluded vessels. Furthermore, improvements in patient selection contribute to achievement of good clinical outcomes after endovascular therapy. This article summarizes findings from recent clinical trials and presents evidence-based guidelines for endovascular interventions in the treatment of ischemic stroke.
缺血性脑卒中仍然是美国成年人死亡和残疾的主要原因之一。根据既定指南，在急性缺血性脑卒中的情况下，闭塞血管的再灌注是标准治疗方法。自 20 世纪 90 年代后期静脉内（IV）重组组织纤溶酶原激活剂（rt-PA）问世以来，在输送溶栓剂的方法和机械开通闭塞血管的装置方面取得了重大进展。此外，患者选择的改进有助于实现血管内治疗后的良好临床转归。本文总结了最近临床试验的结果，并提出了血管内干预治疗缺血性脑卒中的循证指南。
