NMR 测定手性伯胺的绝对构型。
NMR determinations of the absolute configuration of alpha-chiral primary amines.
机构信息
Department of Chemistry and Biological Science, College of Science and Engineering, Aoyama Gakuin University, 5-10-1 Fuchinobe, Chuo-ku, Sagamihara Kanagawa 252-5258, Japan.
出版信息
Org Lett. 2010 Jun 18;12(12):2856-9. doi: 10.1021/ol100951s.
PMID:20462201
Abstract
We have established a methodology to determine the absolute configuration of alpha-chiral primary amines by derivatization to the corresponding imines with each enantiomer of 2'-methoxy-1,1'-binaphthalene-8-carbaldehyde (1). This methodology proceeds on the basis of modified Mosher's method, and sufficiently large Deltadelta(R)(S) values can be obtained to elucidate the stereochemistry of the amines.
摘要
我们建立了一种通过与 2'-甲氧基-1,1'-联萘-8-醛（1）的每个对映体衍生化来确定α-手性伯胺绝对构型的方法。该方法基于改进的 Mosher 方法，并且可以获得足够大的ΔΔ(R)(S) 值来阐明胺的立体化学。
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