Medical Oncology Department, Hospital Universitario Clínico San Carlos, Madrid, Spain.
Clin Transl Oncol. 2010 Apr;12(4):310-4. doi: 10.1007/s12094-010-0510-z.
Glioblastoma multiforme (GBM) is the most aggressive brain tumour in adults and remains incurable despite multimodal intensive treatment regimens. We present a patient with a recurrent glioblastoma who showed coexpression of the epidermal growth factor receptor mutant variant III (EGFRvIII) and the tumour-suppressor protein PTEN. She was treated with the tyrosine kinase inhibitor erlotinib for four months, achieving a partial response with improvement of neurologic symptoms. A review of the pertinent literature supporting the future use of therapies against epidermal growth factor receptor (EGFR) in highgrade gliomas is also provided.
多形性胶质母细胞瘤（GBM）是成人中最具侵袭性的脑肿瘤，尽管采用了多种强化治疗方案，但仍然无法治愈。我们报告了一例复发性胶质母细胞瘤患者，其同时表达表皮生长因子受体突变体 III（EGFRvIII）和肿瘤抑制蛋白 PTEN。她接受了酪氨酸激酶抑制剂厄洛替尼治疗四个月，神经症状改善，部分缓解。还对支持在高级别脑肿瘤中使用针对表皮生长因子受体（EGFR）的治疗方法的相关文献进行了回顾。
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