PTEN磷酸酶的调控
Regulation of the PTEN phosphatase.
作者信息
Gericke Arne, Munson Mary, Ross Alonzo H
机构信息
Chemistry Department, Kent State University, Kent, OH 44242, USA.
出版信息
Gene. 2006 Jun 7;374:1-9. doi: 10.1016/j.gene.2006.02.024. Epub 2006 Mar 14.
Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a phosphatidylinositol phosphate phosphatase and is frequently inactivated in human cancers. The balance between phosphoinositide 3-kinase (PI3K) and PTEN determines PI(3,4,5)P3 levels. PI3K is regulated by a variety of intracellular and extracellular signals, but little is known about the regulation of PTEN. In this article, we review control of PTEN function by phosphorylation as well as by binding of lipid and protein partners.
10号染色体缺失的磷酸酶及张力蛋白同源物（PTEN）是一种磷脂酰肌醇磷酸酶，在人类癌症中经常失活。磷酸肌醇3激酶（PI3K）和PTEN之间的平衡决定了PI(3,4,5)P3的水平。PI3K受多种细胞内和细胞外信号调节，但对PTEN的调节知之甚少。在本文中，我们综述了通过磷酸化以及脂质和蛋白质伴侣结合对PTEN功能的调控。
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