Department of Pulmonary Medicine, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1100, Houston, TX 77030, USA.
Proc Am Thorac Soc. 2010 May;7(3):197-203. doi: 10.1513/pats.200907-075AL.
Although Candida spp. exist as normal flora on much of the human body, life-threatening invasive infections by these organisms have increased in recent decades. Candida spp. are now one of the most common causes of nosocomial blood stream infections worldwide, and patients with critical illness or malignant disease demonstrate particular susceptibility. Risk factors are identifiable for virtually all patients who develop invasive candidiasis, and clinicians must maintain vigilance for Candida infections in the appropriate clinical context, given the attributable mortality. This review addresses the clinical and molecular epidemiology of invasive Candida infections, common clinical manifestations, available diagnostic methods, and current recommendations for initial therapy.
虽然念珠菌属（Candida spp.）在人体的大部分部位存在为正常菌群，但近年来，这些生物体引起的危及生命的侵袭性感染有所增加。念珠菌属（Candida spp.）现在是全球最常见的医院获得性血流感染原因之一，重症或恶性疾病患者表现出特别易感性。几乎所有发生侵袭性念珠菌病的患者都存在可识别的危险因素，鉴于其可导致的死亡率，临床医生必须在适当的临床背景下保持警惕，以预防念珠菌感染。本综述介绍了侵袭性念珠菌感染的临床和分子流行病学、常见临床表现、现有的诊断方法以及初始治疗的当前建议。
