Department of Physics, Laboratory for Thin Films-Nanosystems and Nanometrology, Aristotle University, Thessaloniki, Greece.
Int J Nanomedicine. 2010 Apr 7;5:137-45. doi: 10.2147/ijn.s5787.
Atomic force microscope (AFM) has been used incrementally over the last decade in cell biology. Beyond its usefulness in high resolution imaging, AFM also has unique capabilities for probing the viscoelastic properties of living cells in culture and, even more, mapping the spatial distribution of cell mechanical properties, providing thus an indirect indicator of the structure and function of the underlying cytoskeleton and cell organelles. AFM measurements have boosted our understanding of cell mechanics in normal and diseased states and provide future potential in the study of disease pathophysiology and in the establishment of novel diagnostic and treatment options.
原子力显微镜（AFM）在过去十年中逐渐应用于细胞生物学领域。除了在高分辨率成像方面的应用，AFM 还具有独特的功能，可用于探测培养中的活细胞的粘弹性特性，甚至可以绘制细胞机械特性的空间分布，从而提供细胞骨架和细胞器的结构和功能的间接指标。AFM 测量技术提高了我们对正常和患病状态下细胞力学的认识，并为疾病病理生理学的研究以及新型诊断和治疗方法的建立提供了未来的潜力。
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