Shibasaki T, Yamauchi N, Hotta M, Imaki T, Oda T, Ling N, Demura H
Department of Medicine, Institute of Clinical Endocrinology, Tokyo, Japan.
Life Sci. 1991;48(23):2267-73. doi: 10.1016/0024-3205(91)90342-9.
The effect of interleukin (IL)-1 on the occurrence of stress-induced gastric erosions was examined in rats. The intracerebroventricular (icv) administration of IL-1 beta significantly inhibited the occurrence of water-immersion restraint stress-induced gastric erosion at doses of 200 ng, 500 ng and 1 microgram, whereas the intravenous (iv) administration of IL-1 beta altered the occurrence of gastric erosion only at a dose of 1 microgram. The inhibitory effect of IL-1 alpha icv administered on the occurrence of gastric erosion was found only at a dose of 1 microgram. The inhibitory effect of IL-1 beta icv administered on the occurrence of stress-induced gastric erosion was not influenced by icv administration of alpha-helical CRF(9-41), a corticotropin-releasing factor (CRF) receptor antagonist. Indomethacin completely blocked the inhibitory action of IL-1 beta icv administered on stress-induced gastric erosion. It is concluded from these results that IL-1 acts mainly in the central nervous system to inhibit the occurrence of stress-induced gastric erosion and that the IL-1 beta-induced inhibition of gastric erosion is mediated by prostaglandin in a manner that is independent of brain CRF.
研究了白细胞介素（IL）-1对大鼠应激性胃黏膜糜烂发生的影响。脑室内（icv）注射IL-1β，剂量为200 ng、500 ng和1μg时，显著抑制水浸束缚应激诱导的胃黏膜糜烂的发生，而静脉注射（iv）IL-1β仅在剂量为1μg时改变胃黏膜糜烂的发生情况。脑室内注射IL-1α对胃黏膜糜烂发生的抑制作用仅在剂量为1μg时被发现。脑室内注射促肾上腺皮质激素释放因子（CRF）受体拮抗剂α-螺旋CRF(9-41)不影响脑室内注射IL-1β对应激性胃黏膜糜烂发生的抑制作用。吲哚美辛完全阻断了脑室内注射IL-1β对应激性胃黏膜糜烂的抑制作用。从这些结果得出结论，IL-1主要在中枢神经系统发挥作用以抑制应激性胃黏膜糜烂的发生，并且IL-1β诱导的胃黏膜糜烂抑制作用由前列腺素介导，其方式独立于脑CRF。
