Esposito Marco, Cannizzaro Gioacchino, Bozzoli Paolo, Consolo Ugo, Felice Pietro, Ferri Vittorio, Landriani Stefano, Leone Michele, Magliano Antonio, Pellitteri Guiseppe, Todisco Marzio, Torchio Cinzia
Oral and Maxillofacial Surgery, School of Denstistry, The University of Manchester, Manchester, UK.
Eur J Oral Implantol. 2008 Spring;1(1):23-31.
To evaluate the efficacy of prophylactic antibiotics for dental implant placement.
Twelve Italian private practices agreed to participate in this trial, each centre providing 30 patients. One hour prior to implant placement, patients were randomised, for consumption orally of 2 g amoxicillin or identical placebo tablets. Patients needing bone augmentation procedures were not included. Outcome measures were prosthesis and implant failures, adverse events and post-operative biological complications. Patients were seen 1 week, 2 weeks and 4 months post-operatively.
One centre did not deliver any data and 14 patients had to be excluded from the trial for various reasons. One hundred and fifty-eight patients were evaluated in each group and none dropped out at 4 months. Two prostheses and two implants failed in the antibiotics group, compared with four prostheses and nine implants in the placebo group. There were no statistically significant differences for prosthesis failures, implant losses, complications and side effects.
No statistically significant differences were observed. However, four times more patients in the placebo group experienced implant failures than in the antibiotic group, and this requires further investigation.
评估预防性使用抗生素对牙种植体植入的疗效。
十二家意大利私人诊所同意参与本试验，每个中心提供30名患者。在植入种植体前一小时，患者被随机分组，口服2克阿莫西林或相同的安慰剂片。需要进行骨增量手术的患者未纳入。观察指标为假体和种植体失败情况、不良事件及术后生物学并发症。术后1周、2周和4个月对患者进行随访。
一个中心未提供任何数据，14名患者因各种原因被排除在试验之外。每组评估158名患者，4个月时无一例退出。抗生素组有两个假体和两个种植体失败，而安慰剂组有四个假体和九个种植体失败。假体失败、种植体丢失、并发症和副作用方面无统计学显著差异。
未观察到统计学显著差异。然而，安慰剂组种植体失败的患者人数是抗生素组的四倍，这需要进一步研究。
