Lippa C F, Cohen R, Smith T W, Drachman D A
Department of Neurology, University of Massachusetts Medical Center 01655.
Neurology. 1991 Jun;41(6):882-6. doi: 10.1212/wnl.41.6.882.
We describe the clinical, radiologic, neuropsychological, and neuropathologic features of a 69-year-old man with a 3-year history of progressive transcortical expressive aphasia. Neuropsychological testing showed progressive dysfunction of expressive language. Neuropathologic examination demonstrated focal cortical degeneration involving the left superior frontal gyrus, with swollen achromasic neurons and no evidence of Alzheimer's disease, Pick's disease, Creutzfeldt-Jakob disease, Lewybody disease, or other dementing disorders. This case adds to the known heterogeneity of the underlying pathology of patients with primary progressive aphasia.
我们描述了一名69岁男性的临床、放射学、神经心理学和神经病理学特征，该患者有3年进行性经皮质运动性失语病史。神经心理学测试显示表达性语言功能逐渐衰退。神经病理学检查发现左侧额上回局灶性皮质变性，神经元肿胀且不着色，未发现阿尔茨海默病、皮克病、克雅氏病、路易体病或其他痴呆症的证据。该病例增加了原发性进行性失语患者潜在病理的已知异质性。
