Departments of Surgical Oncology and Molecular Therapeutics, California Oncology Research Institute, Santa Monica, CA, USA.
Expert Rev Anticancer Ther. 2010 May;10(5):723-8. doi: 10.1586/era.10.65.
The management of clinically normal regional lymph nodes in early-stage melanoma has been controversial for over a century. Lymphatic mapping and sentinel lymphadenectomy (LM/SL) has been developed as a minimally invasive surgical technique to stage the regional lymph nodes without the associated morbidity of elective complete lymph node dissection. Multiple retrospective studies have validated the accuracy of LM/SL and the importance of the sentinel nodes as a staging tool for melanoma. Two multicenter, prospective, randomized trials have been performed to validate the data from the Phase II studies and determine if a therapeutic benefit exists for LM/SL.
一个多世纪以来，临床区域淋巴结正常的早期黑色素瘤的管理一直存在争议。淋巴绘图和前哨淋巴结活检术（LM/SL）已被开发为一种微创外科技术，用于分期区域性淋巴结，而不会出现选择性完全淋巴结清扫术相关的发病率。多项回顾性研究验证了 LM/SL 的准确性和前哨淋巴结作为黑色素瘤分期工具的重要性。已经进行了两项多中心、前瞻性、随机试验，以验证 II 期研究的数据，并确定 LM/SL 是否存在治疗益处。
