Troisi Nicola, Dorigo Walter, Lo Sapio Patrizia, Pratesi Giovanni, Pulli Raffaele, Gensini Gian Franco, Pratesi Carlo
Department of Vascular Surgery, University of Florence, Florence, Italy.
Ann Vasc Surg. 2010 Aug;24(6):733-40. doi: 10.1016/j.avsg.2010.01.009. Epub 2010 May 15.
The purpose of this study was to evaluate the effectiveness of a standardized preoperative cardiac assessment in reducing the rate of perioperative cardiac complications in patients undergoing aortic surgery, paying particular attention to the analysis of the factors affecting perioperative cardiac outcomes.
Between January 2005 and August 2008, a total of 531 elective interventions for abdominal aortic aneurysms were performed at our institution. All patients underwent preoperative evaluation on an outpatient basis, which included a standardized cardiac assessment protocol to evaluate perioperative cardiac risk. A surgical (open or endovascular) intervention was performed in all patients and perioperative (<30 days) results in terms of overall and cardiac mortality and morbidity rates were recorded.
Preoperative electrocardiogram, transthoracic echocardiography, and cardiology consultation were performed in all patients. In 348 cases (65.5%), further evaluation of cardiac functional capacity with noninvasive stress testing was recommended. A positive noninvasive stress test was noted in 86 (24.7%) of 348 patients and coronary angiography was performed in 34 (39.5%) of 86 patients. Thirteen of these patients underwent successful coronary revascularization (11 percutaneous transluminal coronary angioplasty, two coronary artery bypass graft) before vascular surgery. Thirty-day overall rate and cardiac mortality rate were 1.1% and 0.6%, respectively, and 30-day overall and cardiac morbidity rates were 11.5% and 6.8%, respectively. Univariate analysis demonstrated that in patients aged >80 years, chronic renal failure, congestive heart failure, valvular heart disease, positive noninvasive stress testing, and open surgical treatment significantly affected 30-day cardiac morbidity; however, only valvular heart disease and positive noninvasive stress testing maintained their significance with multivariate analysis (p = 0.005; 95% CI, 1.6-14.4; and p = 0.02; 95% CI, 1.2-8.1, respectively). None of the examined factors significantly affected 30-day cardiac mortality.
In our experience, the use of a routine preoperative cardiac assessment allowed us to obtain satisfactory perioperative results in patients undergoing abdominal aortic surgery. Very few patients, however, require cardiac revascularization before abdominal aortic surgery. Patients with positive stress test may benefit from an endovascular treatment if anatomically feasible.
本研究的目的是评估标准化术前心脏评估在降低主动脉手术患者围手术期心脏并发症发生率方面的有效性,尤其注重对影响围手术期心脏结局的因素进行分析。
2005年1月至2008年8月期间,我院共对531例腹主动脉瘤进行了择期干预。所有患者均在门诊接受术前评估,其中包括一项标准化心脏评估方案以评估围手术期心脏风险。所有患者均接受了外科(开放或血管腔内)干预,并记录了围手术期(<30天)的总体及心脏死亡率和发病率结果。
所有患者均进行了术前心电图、经胸超声心动图检查及心内科会诊。在348例(65.5%)患者中,建议进一步通过无创负荷试验评估心功能。348例患者中有86例(24.7%)无创负荷试验结果为阳性,其中86例中的34例(39.5%)进行了冠状动脉造影。这些患者中有13例在血管手术前行冠状动脉血运重建成功(11例行经皮冠状动脉腔内血管成形术,2例行冠状动脉旁路移植术)。30天总体死亡率和心脏死亡率分别为1.1%和0.6%,30天总体发病率和心脏发病率分别为11.5%和6.8%。单因素分析表明,年龄>80岁、慢性肾功能衰竭、充血性心力衰竭、瓣膜性心脏病、无创负荷试验结果阳性及开放手术治疗的患者,30天心脏发病率受显著影响;然而,多因素分析显示只有瓣膜性心脏病和无创负荷试验结果阳性仍具有统计学意义(p = 0.005;95%CI,1.6 - 14.4;p = 0.02;95%CI,1.2 - 8.1)。所检查的因素均未对30天心脏死亡率产生显著影响。
根据我们的经验,采用常规术前心脏评估使我们在腹主动脉手术患者中获得了满意的围手术期结果。然而,很少有患者在腹主动脉手术前需要进行冠状动脉血运重建。解剖结构可行的情况下,负荷试验结果阳性的患者可能从血管腔内治疗中获益。