School of Biosciences, University of Birmingham, Birmingham B15 2TT, United Kingdom.
J Bacteriol. 2010 Jul;192(14):3824-8. doi: 10.1128/JB.00218-10. Epub 2010 May 14.
FNR-dependent activation of the Escherichia coli K-12 nrf promoter is downregulated by the nitric oxide-sensitive NsrR protein together with the nucleoid-associated protein IHF, which bind to overlapping targets adjacent to the DNA site for FNR. The NsrR target is inactivated by mutation at the Salmonella enterica serovar Typhimurium nrf promoter.
依赖 FNR 的大肠杆菌 K-12 nrf 启动子的激活受一氧化氮敏感的 NsrR 蛋白与核相关蛋白 IHF 下调,它们与 FNR 的 DNA 结合位点相邻的重叠靶标结合。在沙门氏菌肠炎亚种 nrf 启动子中突变 NsrR 靶标失活。