Gandhi Kaushang, Parikh Purvi, Aronow Wilbert S, Desai Harit, Amin Harshad, Sharma Mala, Rubinstein Arye
Department of Internal Medicine, Westchester Medical Center/New York Medical College, New York, USA.
J Gastrointest Cancer. 2010 Dec;41(4):281-4. doi: 10.1007/s12029-010-9158-8.
While it is well known that patients with common variable immunodeficiency (CVID) are predisposed to various malignancies, primarily non-Hodgkin's lymphoma and gastric carcinomas, to our knowledge no cases of hepatocellular carcinoma have been reported in the absence of preexisting liver disease.
We report a 50-year-old male patient with CVID with a B- and T-cell deficiency. The patient was on prophylactic intravenous gammaglobulin and had received several years earlier a course of rituximab for an autoimmune disorder. He had no history of hepatitis. The patient developed a rapidly progressing hepatocellular carcinoma within 3 to 4 weeks.
Although patients with CVID are predisposed to malignancies such as lymphoma and adenocarcinoma of the stomach, rapidly progressive hepatocellular carcinoma in the absence of any preexisting liver disease has not been described.
虽然众所周知，普通可变免疫缺陷（CVID）患者易患各种恶性肿瘤，主要是非霍奇金淋巴瘤和胃癌，但据我们所知，尚无在无既往肝脏疾病的情况下发生肝细胞癌的病例报告。
我们报告了一名50岁的男性CVID患者，存在B细胞和T细胞缺陷。该患者接受预防性静脉注射丙种球蛋白治疗，数年前因自身免疫性疾病接受过利妥昔单抗治疗疗程。他无肝炎病史。该患者在3至4周内发展为进展迅速的肝细胞癌。
虽然CVID患者易患淋巴瘤和胃腺癌等恶性肿瘤，但尚未有在无任何既往肝脏疾病情况下出现进展迅速的肝细胞癌的描述。
