Kragel P J, Walther M M, Pestaner J P, Filling-Katz M R
Laboratory of Pathology and Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Mod Pathol. 1991 Mar;4(2):210-4.
We compare the expression of four markers of renal tubular differentiation in six renal cell carcinomas, five atypical renal cysts, and five simple renal cysts from six patients with von Hippel-Lindau disease. Proximal tubular markers were expressed by five of six renal cell carcinomas, three of five atypical renal cysts, and zero of five simple renal cysts. Distal tubular markers were expressed by one of six renal cell carcinomas, five of five atypical renal cysts, and four of five simple renal cysts. One of the three atypical cysts which expressed distal tubular markers was associated with a renal cell carcinoma which also expressed distal tubular markers. Our findings suggest that simple renal cysts in von Hippel-Lindau disease arise more commonly from distal rather than proximal tubules, while atypical renal cysts show tubular origin similar to renal cell carcinomas.
我们比较了6例肾细胞癌、5例非典型肾囊肿和6例患有冯·希佩尔-林道病患者的5例单纯肾囊肿中四种肾小管分化标志物的表达情况。六种肾细胞癌中有五种、五种非典型肾囊肿中有三种以及五种单纯肾囊肿中无一表达近端肾小管标志物。六种肾细胞癌中有一例、五种非典型肾囊肿中有五种以及五种单纯肾囊肿中有四种表达远端肾小管标志物。表达远端肾小管标志物的三个非典型囊肿中有一个与同样表达远端肾小管标志物的肾细胞癌相关。我们的研究结果表明，冯·希佩尔-林道病中的单纯肾囊肿更常见于起源于远端而非近端肾小管，而非典型肾囊肿显示出与肾细胞癌相似的肾小管起源。
