Effect of cepharanthine on doxorubicin cytotoxicity in P388 murine leukemia cells in vitro and in vivo.
作者信息
Fujimura T, Furusawa S, Kawauchi H, Takayanagi Y, Sasaki K
机构信息
Department of Pharmacology and Toxicology, Cancer Research Institute, Tohoku College of Pharmacy, Sendai, Japan.
出版信息
Res Commun Chem Pathol Pharmacol. 1991 Feb;71(2):235-8.
PMID:2047569
Abstract
The effect of cepharanthine on the cytotoxicity of doxorubicin (DOX) in p388 leukemia cells was studied in vitro and in vivo. Nontoxic levels of cepharanthine enhanced the sensitivity to doxorubicin in p388 cells in vitro. The potentiation of antitumor activity of DOX by cepharanthine against mice bearing p388 cells was also observed.
摘要
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