Udom C E, Smith T J
Neurosciences Program, Indiana University, Bloomington 47405.
Res Commun Chem Pathol Pharmacol. 1991 Mar;71(3):387-90.
The organophosphate metrifonate has been demonstrated to produce a hypolipidemic effect in the Syrian golden hamster as demonstrated by turbidimetric analysis of lipoprotein precipitation by heparin. A sex-related difference in sensitivity to the hypolipidemia may exist, although metrifonate appears to be an effective serum cholinesterase inhibitor in both sexes. Therefore, metrifonate may be a useful probe in the investigation of organophosphate-induced hypolipidemia.
