促肾上腺皮质激素释放因子受体拮抗剂对新生大鼠快速眼动睡眠的影响
[Effects of CRF receptor antagonist on rem sleep in neonatal rat].
作者信息
Liu Xue-dong, Fan Hong-kun, Zhang Gui-hong, Wang Shu-chun, Zhang Zhao, Feng Ping-fu
机构信息
Department of Physiology, Medical School in Zhengzhou University, Zhengzhou 450052, China.
出版信息
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2010 Feb;26(1):86-9.
OBJECTIVE
To observe the role of NB127914, a CRF R1 receptor antagonist, in the regulation of neonatal sleep/wake cycle.
METHODS
Rat pups were surgically implanted with electrodes at postnatal day(PN) 13. At PN 14, 6 hours polysomnographic recording data were continuously collected before and after administration of various doses of NBI 27914, atropine and the same amount of saline.
RESULTS
Compared with baseline, rapid eye movement (REM) sleep was significantly reduced and was replaced primarily by non-REM (NREM) sleep in all groups treated with NBI, but not with dimethyl sulfoxide/saline. Atropine suppressed REM sleep significantly and increased wakefulness simultaneously.
CONCLUSION
Blockage of corticotropin-releasing factor (CRF) R1 receptors deprives neonatal rat REM sleep.
目的
观察促肾上腺皮质激素释放因子（CRF）R1受体拮抗剂NB127914在调节新生大鼠睡眠/觉醒周期中的作用。
方法
在出生后第13天（PN13）对新生大鼠进行手术植入电极。在PN14，在给予不同剂量的NB127914、阿托品和等量生理盐水前后，连续收集6小时的多导睡眠图记录数据。
结果
与基线相比，所有接受NB127914治疗的组中，快速眼动（REM）睡眠显著减少，主要被非快速眼动（NREM）睡眠取代，但接受二甲基亚砜/生理盐水治疗的组未出现此情况。阿托品显著抑制REM睡眠并同时增加觉醒。
结论
阻断CRF R1受体会剥夺新生大鼠的REM睡眠。
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