Department of Chemistry, Scripps Florida, Jupiter, Florida 33458, USA.
Org Lett. 2010 Jun 18;12(12):2706-9. doi: 10.1021/ol1007444.
Delta-methyl-substituted homoallylic alcohols 2 were prepared in 71-88% yield, E:Z >30:1 and 93% to >95% ee via BF(3).Et(2)O-promoted allylboration with alpha-Me-allylboronate 1. The origin of high (E)-selectivity is proposed.
通过 BF(3)·Et(2)O 促进的 α-Me-烯丙基硼酸酯 1 的烯丙基硼化反应,以 71-88%的产率、E:Z >30:1 和 93%至>95%ee 得到了 δ-甲基取代的偕丙醇 2。提出了高(E)选择性的起源。