Flaten M A, Gråwe R W, Dahl C B, Haug T
Department of Somatic Psychology, University of Bergen, Norway.
Scand J Psychol. 1991;32(1):70-8. doi: 10.1111/j.1467-9450.1991.tb00854.x.
The purpose of the first experiment was to investigate whether diazepam could acquire anxiogenic properties by signalling an aversive event. Rats were trained in an operant chamber in the pentylenetetrazol (PTZ) model of anxiety. Thereafter the animals were divided into groups that received classical diazepam conditioning (Group 1), and conditioning of diazepam + tone (Group 2). In the test phase diazepam was injected prior to placement in the operant chamber. Group 2 selected the PTZ-appropriate lever more often than the other groups, indicating that the tone induced anxiety, and diazepam did not. Tones and shock may therefore be more easily associated than diazepam and shock. The second experiment investigated this. Rats were trained the same way as in the first experiment. Thereafter the experimental group received injections of a small dose of diazepam prior to a second injection of a large dose of diazepam. The hypothesis was that a compensatory anxiogenic conditional response to diazepam's anxiolytic effect should be elicited by the small dose. There were no differences between the groups in lever selection, indicating that a compensatory anxiogenic response was not elicited.
第一个实验的目的是研究地西泮是否会通过传递厌恶事件的信号而获得致焦虑特性。大鼠在戊四氮（PTZ）焦虑模型的操作箱中接受训练。此后，将动物分为接受经典地西泮条件作用的组（第1组）和接受地西泮+音调条件作用的组（第2组）。在测试阶段，在将大鼠放入操作箱之前注射地西泮。第2组比其他组更频繁地选择与PTZ相关的杠杆，这表明音调会诱发焦虑，而地西泮不会。因此，音调与电击可能比地西泮与电击更容易关联。第二个实验对此进行了研究。大鼠的训练方式与第一个实验相同。此后，实验组在第二次注射大剂量地西泮之前先注射小剂量地西泮。假设是小剂量地西泮应引发对其抗焦虑作用的代偿性致焦虑条件反应。各组在杠杆选择上没有差异，表明未引发代偿性致焦虑反应。
