与三联抗生素治疗相关的未成熟恒切牙牙齿变色：病例报告。
Tooth discoloration of immature permanent incisor associated with triple antibiotic therapy: a case report.
机构信息
Department of Conservative Dentistry, College of Dentistry, Yonsei University, Seoul, Korea.
出版信息
J Endod. 2010 Jun;36(6):1086-91. doi: 10.1016/j.joen.2010.03.031.
INTRODUCTION
A triple antibiotic mixture of ciprofloxacin, metronidazole, and minocycline was used as an intracanal medicament in an attempt to disinfect the root canal system for revascularization of a tooth with a necrotic pulp. However, discoloration developed after applying the triple antibiotic mixture.
METHODS
Six weeks after a triple antibiotic paste had been applied to the root canal of tooth #8 of a 7-year-old girl, the tooth showed a dark discoloration. An in vitro experiment with human extracted teeth was performed to determine which of the 3 antibiotics caused the tooth discoloration. Another experiment was then carried out to examine whether a currently used dentin bonding agent would prevent or reduce such discoloration. The degree of discoloration was assessed by using a colorimeter.
RESULTS
Among the components of the triple antibiotic paste, only minocycline caused the tooth discoloration. Moreover, the dentin bonding agent reduced the intensity of the discoloration but did not prevent it.
CONCLUSIONS
The possible esthetic problems with the tooth color should be considered when using minocycline as a canal medication.
简介
曾将环丙沙星、甲硝唑和米诺环素的三联抗生素混合物用作根管内药物，以尝试对发生牙髓坏死的牙齿的根管系统进行消毒，从而实现血运重建。然而，在应用三联抗生素混合物后，牙齿出现了变色。
方法
在 7 岁女孩的 8 号牙的根管中应用三联抗生素糊剂 6 周后，该牙出现了暗黑色变色。我们进行了一项离体人牙实验，以确定是 3 种抗生素中的哪一种导致了牙齿变色。然后进行了另一个实验，以检查目前使用的牙本质粘结剂是否可以预防或减少这种变色。使用比色计评估变色程度。
结果
在三联抗生素糊剂的成分中，只有米诺环素导致了牙齿变色。此外，牙本质粘结剂降低了变色的强度，但不能阻止变色。
结论
在将米诺环素用作根管内药物时，应考虑到牙齿颜色可能出现的美观问题。
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