Ron Akshata, Jena Debkant, Dwivedi Vartul, Sharma Durgesh Kumar, Late Laxmikant, Jethlia Ankur, Makkad Ramanpal Singh
Department of Dentistry, KLE, Jagadguru Gangadhar Mahaswamigalu Moorusavirmath Medical College, Hubballi, Karnataka, India.
Department of Conservative Dentistry and Endodontics, Kalinga Institute of Dental Sciences, KIIT University, Bhubaneswar, Odisha, India.
J Pharm Bioallied Sci. 2024 Jul;16(Suppl 3):S2162-S2164. doi: 10.4103/jpbs.jpbs_110_24. Epub 2024 Apr 24.
Antimicrobial endodontic intracanal medicaments play a vital role along with biomechanical preparation in the elimination of bacteria present in the pulp area to achieve success in endodontic therapy.
The present research was conducted with the objective of evaluating and comparing intracanal medicaments regarding antibacterial properties against .
One hundred and twenty healthy human premolars of the mandible were used. All premolar crowns were removed, keeping the standardized length of the root as 15 mm. Category 1 received triple antibiotic paste (TAP) ( = 30), Category 2 received double antibiotic paste (DAP) ( = 30), Category 3 received augmentin ( = 30), and Category 4 received calcium hydroxide ( = 30). Hygienic paper points were placed in each root canal, then they were moved to a tube containing 1 mL of brain-heart infusion medium and left there for bacteriological testing. Colony-forming units (CFUs) of were then observed and counted after the plates had been incubated overnight at a temperature of 37°C.
During intracategory comparisons, there was a significant reduction in colonies of in each category ( ≤ 0.001). When there were intercategory comparisons, there was a maximum reduction in CFU in specimens of Category 1 (TAP) followed by Category 3 (Augmentin) and Category 2 (DAP).
Intracanal medicaments like TAP, DAP, and augmentin are effective against root canal .
抗菌性牙髓腔根管内药物在牙髓腔细菌的清除过程中,与生物力学预备同样发挥着至关重要的作用,从而在根管治疗中取得成功。
本研究旨在评估和比较根管内药物对……的抗菌性能。
使用120颗健康的下颌前磨牙。所有前磨牙牙冠均被去除,使牙根标准化长度保持为15毫米。第1组接受三联抗生素糊剂(TAP)(n = 30),第2组接受双联抗生素糊剂(DAP)(n = 30),第3组接受阿莫西林克拉维酸钾(n = 30),第4组接受氢氧化钙(n = 30)。将卫生纸尖放入每个根管中,然后转移至装有1毫升脑心浸液培养基的试管中,并放置在那里进行细菌学检测。平板在37℃下过夜培养后,观察并计数粪肠球菌的菌落形成单位(CFUs)。
在组内比较中,每组粪肠球菌菌落均有显著减少(P≤0.001)。组间比较时,第1组(TAP)标本中的CFU减少最多,其次是第3组(阿莫西林克拉维酸钾)和第2组(DAP)。
TAP、DAP和阿莫西林克拉维酸钾等根管内药物对根管粪肠球菌有效。