Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands.
Psychiatry Res. 2010 Aug 30;179(1):47-52. doi: 10.1016/j.psychres.2009.10.020. Epub 2010 May 15.
Information about mood reactions to naturally occurring stress in remitted bipolar patients may help elucidate the mechanism by which stressors influence the propensity to manic or depressive relapse in these patients. Using the experience sampling method (ESM), we therefore investigated negative and positive mood states and their reactivity to daily hassles and uplifts in 38 outpatients with remitted bipolar disorder and 38 healthy volunteers. Multilevel regression analyses confirmed that mean levels of negative affect (NA) were higher and positive affect (PA) lower in bipolar patients. Reactivity of NA and PA to hassles and uplifts in bipolar patients was similar to controls and was unrelated to the number of previous episodes. Bipolar patients with subsyndromal depressive symptoms, however, showed particularly large NA responses to daily hassles, which they also rated as more stressful. Subsyndromal depressive symptoms in patients with remitted bipolar disorder thus appear to increase sensitivity to everyday stressors.
关于缓解期双相情感障碍患者对自然发生的应激的情绪反应的信息，可能有助于阐明应激源如何影响这些患者发生躁狂或抑郁复发的倾向的机制。因此，我们使用经验取样法（ESM），调查了 38 名缓解期双相情感障碍患者和 38 名健康志愿者的负性和正性情绪状态，以及他们对日常烦恼和振奋事件的反应。多层次回归分析证实，双相情感障碍患者的负性情绪（NA）平均水平较高，正性情绪（PA）水平较低。双相情感障碍患者的 NA 和 PA 对烦恼和振奋事件的反应与对照组相似，与既往发作次数无关。然而，有亚临床抑郁症状的双相情感障碍患者对日常烦恼的 NA 反应特别大，他们也认为这些烦恼更有压力。因此，缓解期双相情感障碍患者的亚临床抑郁症状似乎增加了对日常应激源的敏感性。
