Laboratories for Organic Chemistry, Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.
Org Biomol Chem. 2010 Jun 28;8(13):3045-54. doi: 10.1039/b924749a. Epub 2010 May 17.
Chiral palladium phosphine complexes have been employed in the chiral separation of amino acids and phenylalanine analogues in particular. The use of (S)-xylyl-BINAP as a ligand for the palladium complex in enantioselective liquid-liquid extraction allowed the separation of the phenylalanine analogues with the highest operational selectivity reported to date. (31)P NMR, FTIR, FIR, UV-Vis, CD and Raman spectroscopy methods have been applied to gain insight into the binding mechanism of the amino acid substrates with the chiral palladium phosphine complexes. A complexation in a bidentate fashion is proposed.
手性钯膦配合物已被用于手性拆分氨基酸和苯丙氨酸类似物，特别是。（S）-二甲氧基联苯膦作为手性钯配合物的配体，用于对映选择性液-液萃取，使得迄今为止报道的操作选择性最高的苯丙氨酸类似物得以分离。（31）磷 NMR、FTIR、FIR、UV-Vis、CD 和拉曼光谱方法已被应用于深入了解氨基酸底物与手性钯膦配合物的结合机制。提出了一种以螯合方式进行的配位。
