[Assessment of the efficacy of de-nol and bismuth subnitrate treatment of patients with associated peptic ulcer and pyloric Helicobacter infection (experimental and clinical studies)].

The duration of colloid bismuth subcitrate (de-nol) and bismuth subnitrate (BSN) fixation on the mucosa was studied in animal experiments and in patients suffering from peptic ulcer using scanning electron microscopy and roentgenospectral analysis. In patients suffering from peptic ulcer with pyloric chelicobacter (PC), a study was made of the relationship between the duration of bismuth drugs fixation on the mucosa and the degree of PC elimination as well as of the therapeutic efficacy in such patients of the use of de-nol and BSN. The characteristic features of the structure of de-nol granules were defined, enabling those granules to be fixed on the mucosa for more than 12 hours. In contrast to BSN, de-nol was found to possess a higher assanation capacity as regards PC. After 3 weeks of the treatment the therapeutic efficacy of de-nol was 75%, that of BSN 54%. Scanning electron microscopy is an effective method of demonstrating bismuth salts on the mucosa in negligible concentrations.