Institut Européen de Chimie et Biologie, Université de Bordeaux-CNRS UMR5248 and UMS3033, 2 rue Robert Escarpit, 33607 Pessac, France.
J Am Chem Soc. 2010 Jun 16;132(23):7858-9. doi: 10.1021/ja102794a.
A helical aromatic oligoamide foldamer encapsulates tartaric acid with exceptional affinity, selectivity, and diastereoselectivity. The structure of the complex has been elucidated both in solution by NMR spectroscopy and in the solid state by X-ray crystallography, making it possible to rationalize the strong effects observed, particularly the role of hydrogen bonds between the hydroxyl and carboxylic acid groups of tartaric acid and the inner wall of the helically folded capsule, which completely surrounds the guest and insulates it from the solvent.
一种螺旋芳香寡酰胺折叠体对酒石酸具有优异的亲和力、选择性和非对映选择性。该配合物的结构已通过 NMR 光谱在溶液中以及通过 X 射线晶体学在固态中得到阐明，这使得能够合理化所观察到的强效应，特别是酒石酸的羟基和羧基与螺旋折叠胶囊内壁之间氢键的作用，胶囊完全包围客体并将其与溶剂隔离。
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