手性光学传感：概念性介绍。

Department of Organic Chemistry, University of Vigo, 36310 Vigo, Spain.

Department of Food Science and Technology, Biotechnical Faculty, University of Ljubljana, Kongresni trg 12, 1000 Ljubljana, Slovenia.

Sensors (Basel). 2020 Feb 12;20(4):974. doi: 10.3390/s20040974.

Chiroptical responses have been an essential tool over the last decades for chemical structural elucidation due to their exceptional sensitivity to geometry and intermolecular interactions. In recent times, there has been an increasing interest in the search for more efficient sensing by the rational design of tailored chiroptical systems. In this review article, advances made in chiroptical systems towards their implementation in sensing applications are summarized. Strategies to generate chiroptical responses are illustrated. Theoretical approaches to assist in the design of these systems are discussed. The development of efficient chiroptical reporters in different states of matter, essential for the implementation in sensing devises, is reviewed. In the last part, remarkable examples of chiroptical sensing applications are highlighted.

手性光学响应在过去几十年中一直是化学结构阐明的重要工具，因为它们对手性和分子间相互作用的变化非常敏感。最近，人们越来越关注通过合理设计定制手性体系来寻找更有效的传感方法。在这篇综述文章中，总结了在手性体系方面的进展，这些进展旨在将其应用于传感应用中。本文展示了产生手性光学响应的策略。讨论了有助于设计这些系统的理论方法。综述了不同物质状态下高效手性报告分子的发展，这对于在传感设备中的应用是必不可少的。最后一部分强调了手性光学传感应用的一些显著例子。