Bergmann F, Feinmesser M, Yagen B
Department of Pharmacology, School of Pharmacy, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Toxicol Lett. 1991 Jun;57(1):1-9. doi: 10.1016/0378-4274(91)90113-k.
The antibiotic cycloheximide inhibits protein synthesis in eukaryotic cells. This overall effect is similar to that of T-2 toxin, but the mechanism of intoxication by these two inhibitors are different. This is shown here by intracerebral injections of mixtures of T-2 toxin and cycloheximide, leading to potentiation of their toxic effects. The histopathology of cerebral intoxication by the two compounds is similar, but after cycloheximide the lesions appear earlier, and repair is faster.
抗生素放线菌酮抑制真核细胞中的蛋白质合成。这种总体效果与T-2毒素相似，但这两种抑制剂的中毒机制不同。脑内注射T-2毒素和放线菌酮的混合物表明了这一点，这会导致它们的毒性作用增强。这两种化合物引起的脑中毒组织病理学相似，但放线菌酮中毒后病变出现得更早，修复也更快。
