镉致肾小管功能障碍时血清1,25-二羟维生素D和25-羟维生素D水平的初步研究

Preliminary study on serum levels of 1,25-dihydroxyvitamin D and 25-hydroxyvitamin D in cadmium-induced renal tubular dysfunction.

作者信息

Aoshima K, Kasuya M

机构信息

Department of Public Health, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.

出版信息

Toxicol Lett. 1991 Jun;57(1):91-9. doi: 10.1016/0378-4274(91)90123-n.

DOI:10.1016/0378-4274(91)90123-n

PMID:2048165

Abstract

Serum 1,25-dihydroxyvitamin D [1,25(OH)2D] and 25-hydroxyvitamin D [25(OH)D] were measured in 7 women living in a cadmium-polluted area in Toyama, Japan. Despite the fact that these subjects had severe proximal renal tubular dysfunction showing increased fractional excretion of beta 2-microglobulin (FE beta 2-m) ranging from 9.7-49.1% with a mean of 30.7%, the levels of serum 1,25(OH)2D, which is produced in the proximal tubules, were within the normal range in 6 subjects. Significant correlations were found between 1,25(OH)2D and creatinine clearance (r = 0.802, P less than 0.05), and FE beta 2-m (r = -0.829, P less than 0.05), respectively. These results suggest that renal production of 1,25(OH)2D decreases with progression of cadmium-induced renal tubular dysfunction.

摘要

对居住在日本富山镉污染地区的7名女性进行了血清1,25 - 二羟基维生素D [1,25(OH)₂D] 和25 - 羟基维生素D [25(OH)D] 的检测。尽管这些受试者存在严重的近端肾小管功能障碍，表现为β₂ - 微球蛋白分数排泄率（FEβ₂ - m）升高，范围在9.7% - 49.1%，平均为30.7%，但在6名受试者中，近端肾小管产生的血清1,25(OH)₂D水平仍在正常范围内。分别发现1,25(OH)₂D与肌酐清除率（r = 0.802，P < 0.05）以及FEβ₂ - m（r = -0.829，P < 0.05）之间存在显著相关性。这些结果表明，随着镉诱导的肾小管功能障碍的进展，肾脏产生1,25(OH)₂D的能力下降。