采用多重微球检测试剂盒分析急性肾损伤的发病机制：巢式病例对照初步研究。
Exploration of disease mechanism in acute kidney injury using a multiplex bead array assay: a nested case-control pilot study.
机构信息
Kidney & Dialysis Research Laboratory, St Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA, USA.
出版信息
Biomarkers. 2010 Aug;15(5):436-45. doi: 10.3109/1354750X.2010.485252.
Abstract
BACKGROUND
Acute kidney injury (AKI) following cardiac surgery with cardiopulmonary bypass (CPB) causes increased morbidity and mortality.
OBJECTIVE
To evaluate the plasma profile of biomarkers potentially involved in AKI development following CPB.
METHODS
In a nested case-control study, plasma levels of 27 biomarkers in 11 AKI cases were compared with 25 controls.
RESULTS
Pre-CPB, plasma levels of epidermal growth factor and macrophage inflammatory protein-1beta, 2 h following CPB, soluble vascular cell adhesion molecule-1 (sVCAM-1), fractalkine and macrophage inflammatory protein-1alpha, and at later time points, sVCAM-1 and interleukin-6 were associated with AKI.
CONCLUSION
Biomarkers associated with AKI following CPB may merit further study.
摘要
背景
体外循环心脏手术后急性肾损伤（AKI）会增加发病率和死亡率。
目的
评估与体外循环后 AKI 发展相关的潜在生物标志物的血浆谱。
方法
在一项巢式病例对照研究中，将 11 例 AKI 病例与 25 例对照的血浆生物标志物水平进行了比较。
结果
CPB 前，表皮生长因子和巨噬细胞炎症蛋白-1β的血浆水平、CPB 后 2 小时，可溶性血管细胞黏附分子-1（sVCAM-1）、 fractalkine 和巨噬细胞炎症蛋白-1α，以及在后期时间点，sVCAM-1 和白细胞介素-6 与 AKI 相关。
结论
与 CPB 后 AKI 相关的生物标志物可能值得进一步研究。
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