Gusek W
Klin Padiatr. 1978 Jan;190(1):44-53.
Histologic studies indicate that the cycasin-induced Wilms' tumor in the rat is equal to human nephroblastoma in appearance. Therefore, it may represent an interesting system for experimental oncology. In electron microscopy, the spindle cells of the sarcoma region mostly represent tubular cells. Besides, the author's results showed that preexisting mesenchyma cells and blood vessels also form part of the tumor. Electron microscopy studies have shown that cycasin feeding will lead to early cellular changes indicating that cycasin exercises a nucleotoxic effect. Present results do not favor the dysontogenic concept of the formation of Wilms' tumor, since this tumor can be induced diaplacentally.
组织学研究表明，大鼠中由苏铁素诱导产生的肾母细胞瘤在外观上与人类肾母细胞瘤相似。因此，它可能是实验肿瘤学中一个有趣的研究系统。在电子显微镜下，肉瘤区域的梭形细胞大多代表肾小管细胞。此外，作者的研究结果表明，预先存在的间充质细胞和血管也是肿瘤的一部分。电子显微镜研究表明，喂食苏铁素会导致早期细胞变化，这表明苏铁素具有核毒性作用。目前的研究结果不支持肾母细胞瘤形成的发育异常概念，因为这种肿瘤可经胎盘诱导产生。
