Department of Entomology/Institute of Biotechnology, National Taiwan University, Taipei, Taiwan.
Insect Mol Biol. 2010 Mar;19 Suppl 2:75-85. doi: 10.1111/j.1365-2583.2009.00940.x.
In the dipteran Drosophila, the genes bicoid and hunchback work synergistically to pattern the anterior blastoderm during embryogenesis. bicoid, however, appears to be an innovation of the higher Diptera. Hence, in some non-dipteran insects, anterior specification instead relies on a synergistic interaction between maternally transcribed hunchback and orthodenticle. Here we describe how orthologues of hunchback and orthodenticle are expressed during oogenesis and embryogenesis in the parthenogenetic and viviparous form of the pea aphid, Acyrthosiphon pisum. A. pisum hunchback (Aphb) mRNA is localized to the anterior pole in developing oocytes and early embryos prior to blastoderm formation - a pattern strongly reminiscent of bicoid localization in Drosophila. A. pisum orthodenticle (Apotd), on the other hand, is not expressed prior to gastrulation, suggesting that it is the asymmetric localization of Aphb, rather than synergy between Aphb and Apotd, that regulates anterior specification in asexual pea aphids.
在双翅目果蝇中，bicoid 和 hunchback 基因协同作用，在胚胎发生过程中对前原肠胚进行模式化。然而，bicoid 似乎是高等双翅目昆虫的创新。因此，在一些非双翅目昆虫中，前体的特化反而依赖于母源转录的 hunchback 和 orthodenticle 之间的协同相互作用。在这里，我们描述了豌豆蚜（Acyrthosiphon pisum）孤雌生殖和胎生形式的卵母细胞发生和胚胎发生过程中 hunchback 和 orthodenticle 的同源物是如何表达的。A. pisum hunchback（Aphb）mRNA 在卵母细胞和早期胚胎发育过程中定位于前极，在原肠胚形成之前-这一模式强烈地让人想起果蝇中的 bicoid 定位。另一方面，A. pisum orthodenticle（Apotd）在原肠胚形成之前不表达，这表明是 Aphb 的不对称定位，而不是 Aphb 和 Apotd 之间的协同作用，调节了无性豌豆蚜的前体特化。
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