[一名重症监护患者因对奥司他韦耐药的新型甲型H1N1流感导致的致命性肺炎]

[Fatal pneumonitis due to oseltamivir-resistant new influenza A(H1N1) in the case of an intensive care patient].

作者信息

Aardema Heleen, Tulleken Jaap E, van den Biggelaar Ries J M, Wolters Bert A, de Jager Corine M, Boucher Charles A B, Riezebos-Brilman Annelies

机构信息

Universitair Medisch Centrum Groningen, Afd. Intensive Care Volwassenen, The Netherlands.

出版信息

Ned Tijdschr Geneeskd. 2010;154:A1634.

PMID:20482913

Abstract

A 58-year-old man was submitted to our intensive care ward with respiratory failure due to pneumonitis. He had previously been treated for non-Hodgkin lymphoma by autologous stem cell transplantation, as a result of which bone marrow function was reduced. Further analysis showed infection with new influenza A(H1N1); typing revealed an oseltamivir-resistant subpopulation (H275Y). The patient was treated with oseltamivir and intravenously with zanamivir, but died of respiratory disease progression. This is the first published case of oseltamivir-resistant new influenza A(H1N1) infection in the Netherlands.

摘要

一名58岁男性因肺炎导致呼吸衰竭被送入我们的重症监护病房。他此前因非霍奇金淋巴瘤接受了自体干细胞移植治疗，导致骨髓功能下降。进一步分析显示感染了新型甲型H1N1流感；分型显示存在对奥司他韦耐药的亚群（H275Y）。该患者接受了奥司他韦治疗，并静脉注射了扎那米韦，但最终因呼吸疾病进展而死亡。这是荷兰首例关于对奥司他韦耐药的新型甲型H1N1流感感染的报道病例。