Beck-Nielsen Signe Sparre, Pedersen Susanne Møller, Kassem Moustapha, Rasmussen Lars Melholt
H.C. Andersen Børnehospital, Afdeling for Biokemi, Farmakologi og Genetik, Odense Universitetshospital, 5000 Odense C, Denmark.
Ugeskr Laeger. 2010 May 17;172(20):1521-7.
Fibroblast growth factor 23 (FGF23) is a recently identified phosphatonin. Its main physiological functions are to maintain serum phosphate within its reference range and to counter regulate the effects of vitamin D. Diseases correlated to high serum values of FGF23 are hypophosphatemic rickets, fibrous dysplasia, and tumour-induced osteomalacia. In contrast, hyperphosphatemic tumoral calcinosis is associated with accelerated degradation of FGF23. Measuring FGF23 serves as a differential diagnostic tool in elucidating conditions of long-lasting hypophosphatemia.
成纤维细胞生长因子23（FGF23）是一种最近发现的磷调节素。其主要生理功能是将血清磷酸盐维持在参考范围内，并对抗维生素D的作用。与FGF23血清值升高相关的疾病有低磷性佝偻病、骨纤维发育不良和肿瘤性骨软化症。相反，高磷性肿瘤性钙化与FGF23的加速降解有关。检测FGF23可作为鉴别诊断工具，用于阐明长期低磷血症的情况。
