Department of Reproductive Medicine and Gynaecology, University Medical Centre Utrecht, The Netherlands.
Reprod Biomed Online. 2007;14 Spec No 1:27-37. doi: 10.1016/S1472-6483(10)61456-3.
Implantation is a complicated process that requires the orchestration of a series of events involving both the embryo and the endometrium. Even with the transfer of high quality embryos, implantation rates remain relatively low. The growing tendency towards transferring fewer embryos provides further incentives to improve implantation rates. In this article, the various clinical strategies employed to increase the chance of implantation are reviewed. Embryo transfer technique is a critical step in assisted reproductive technology cycles. Recent studies have shown significant improvements in clinical pregnancy rates resulting from careful embryo transfer technique, appropriate catheter type and placing for embryo transfer. Increasingly, adjuvant pharmaceutical therapies are also being applied with the aim of improving embryo implantation. However, the evidence for their efficacy and safety is limited. Recent evidence suggests that adoption of milder ovarian stimulation regimens may provide a more effective clinical approach to improving implantation, since beneficial effects have been shown for both endometrial receptivity and embryo quality.
着床是一个复杂的过程，需要胚胎和子宫内膜协同一系列事件。即使移植了高质量的胚胎，着床率仍然相对较低。越来越倾向于移植较少数量的胚胎，这进一步促使人们提高着床率。本文综述了提高着床率的各种临床策略。胚胎移植技术是辅助生殖技术周期中的关键步骤。最近的研究表明，通过精心的胚胎移植技术、适当的导管类型和胚胎移植位置，临床妊娠率有了显著提高。越来越多的辅助药物治疗也被应用，旨在改善胚胎着床。然而，其疗效和安全性的证据有限。最近的证据表明，采用较温和的卵巢刺激方案可能提供一种更有效的改善着床的临床方法，因为已显示对子宫内膜容受性和胚胎质量都有有益的影响。
