Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, China.
Cancer Lett. 2010 Nov 1;297(1):9-17. doi: 10.1016/j.canlet.2010.04.019. Epub 2010 May 18.
Previous studies in our laboratory have suggested that gankyrin expression is correlated with a malignant phenotype in colorectal cancer. Here, we investigated the possible role of gankyrin in pancreatic carcinogenesis. Gankyrin expression was significantly increased in pancreatic cancer compared to non-cancerous tissues. This expression significantly enhanced cancer cell proliferation and growth in vitro and in vivo. Suppression of gankyrin downregulated cyclin A, cyclin D1, cyclin E, CDK2, CDK4, PCNA and p-Rb but upregulated p27, Rb and p53. However, gankyrin overexpression led to opposite results. Thus, gankyrin could enhance pancreatic cancer cell proliferation by promoting cell cycle progression and p53 degradation.
先前我们实验室的研究表明，gankyrin 的表达与结直肠癌的恶性表型相关。在这里，我们研究了 gankyrin 在胰腺癌发生中的可能作用。与非癌组织相比，gankyrin 在胰腺癌中的表达显著增加。这种表达显著增强了体外和体内的癌细胞增殖和生长。gankyrin 的抑制下调了细胞周期蛋白 A、D1、E、CDK2、CDK4、PCNA 和 p-Rb，但上调了 p27、Rb 和 p53。然而，gankyrin 的过表达导致了相反的结果。因此，gankyrin 可以通过促进细胞周期进程和 p53 降解来增强胰腺癌细胞的增殖。
