Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA 01609, USA.
IEEE Trans Biomed Eng. 2010 Aug;57(8):1937-44. doi: 10.1109/TBME.2010.2045377. Epub 2010 May 17.
A nonleast-squares (non-LS) based method is presented for modeling time-varying (TV) nonlinear systems. The proposed method combines basis function technique and minimization of hypersurface distance (MHD) to combat TV and nonlinear dynamics, respectively. The performance of TVMHD is compared to the LS and total LS methods using simulation examples as well as human heart rate data recorded during different body positions. With all data, TVMHD significantly outperforms the two other methods by a factor of one order of magnitude; the LS-based methods require double the number of parameters than TVMHD requires to obtain similar residual error values. The significance of TVMHD is that due to its accurate parameter estimates concomitant with a fewer number of parameters, we now have the possibility of pinpointing parameters that may be of physiological importance, where such application will be especially useful in discriminating diseased conditions. Furthermore, our algorithm allows discrimination of model terms, which are TV or time invariant, by examining those basis function coefficients that are designed to capture TV dynamics. However, it should be noted that the main disadvantage of TVMHD is that it requires significantly greater computational time than the LS-based methods.
本文提出了一种基于非最小二乘(non-LS)的方法,用于对时变(TV)非线性系统进行建模。所提出的方法结合了基函数技术和超曲面距离最小化(MHD),分别用于对抗 TV 和非线性动力学。使用仿真示例以及在不同体位下记录的人类心率数据,将 TVMHD 的性能与 LS 和总 LS 方法进行了比较。对于所有数据,TVMHD 的性能均优于另外两种方法一个数量级;LS 方法所需的参数数量是 TVMHD 的两倍,才能获得相似的残差值。TVMHD 的重要意义在于,由于其准确的参数估计和较少的参数数量,我们现在有可能确定可能具有生理重要性的参数,这种应用在区分疾病状况时将特别有用。此外,我们的算法允许通过检查旨在捕获 TV 动态的那些基函数系数,来区分 TV 或时不变的模型项。但是,应该注意的是,TVMHD 的主要缺点是它需要比基于 LS 的方法显著更多的计算时间。