CD4 on the road to coreceptor status.
作者信息
Vignali Dario A A
机构信息
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105-3678, USA.
出版信息
J Immunol. 2010 Jun 1;184(11):5933-4. doi: 10.4049/jimmunol.1090037.
Abstract
摘要
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Inhibition of T cell receptor-coreceptor interactions by antagonist ligands visualized by live FRET imaging of the T-hybridoma immunological synapse.通过T杂交瘤免疫突触的实时荧光共振能量转移成像观察拮抗剂配体对T细胞受体-共受体相互作用的抑制作用。
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Differential clustering of CD4 and CD3zeta during T cell recognition.T细胞识别过程中CD4和CD3ζ的差异聚集
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Profound enhancement of T cell activation mediated by the interaction between the TCR and the D3 domain of CD4.TCR与CD4的D3结构域相互作用介导的T细胞活化显著增强。
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The two membrane proximal domains of CD4 interact with the T cell receptor.CD4的两个膜近端结构域与T细胞受体相互作用。
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Helper T-cell development in the absence of CD4-p56lck association.在缺乏CD4-p56lck关联的情况下辅助性T细胞的发育
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Mouse CD4 binds MHC class II with extremely low affinity.小鼠CD4与II类主要组织相容性复合体的结合亲和力极低。
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