小 RNA 指导造血细胞的分化和功能。

Small RNAs guide hematopoietic cell differentiation and function.

机构信息

Immune Disease Institute and Program in Cellular and Molecular Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

出版信息

J Immunol. 2010 Jun 1;184(11):5939-47. doi: 10.4049/jimmunol.0902567.

DOI:10.4049/jimmunol.0902567

PMID:20483778

Abstract

MicroRNAs (miRNAs) are key regulators of gene expression that help direct normal differentiation and malignant transformation of hematopoietic cells. This review summarizes our current knowledge of how miRNAs function in normal and malignant hematopoiesis and how miRNAs might be applied for disease treatment.

摘要

微小 RNA（miRNAs）是基因表达的关键调节因子，有助于指导造血细胞的正常分化和恶性转化。这篇综述总结了我们目前对 miRNAs 在正常和恶性造血中作用的认识，以及 miRNAs 如何应用于疾病治疗。